Bill Cipher and Dipper Pines are both magic performing witches and are in a relationship together. They live in the Shack. Mabel and Dipper are both female. Mabel and Pacifica are dating and are in California.
Stan and Ford are still sailing. Ford doesn't like Bill while Stan doesn't really care. Soos and Melody are living in Portland, and Wendy's in college.
Bill's family is still alive- his aunt/uncle Pi- they're never very clear about their gender- his brother Tad, and his younger sister Jill. Jill and Pi are the only people he's talking to currently since he and Tad don't get along.