125 years have passed since the second Bloody Valentine war has ended; it is now C.E.99, a year shy of reaching the century year in the Cosmic Era calendar. The story takes place in ORB, a once prosperous country housing both Naturals and Coordinators, now still recovering from their darkest moment in their country's history that took place 10 years ago.
Anti-coordinator movements have picked up heat during the course of the years with the organization O.T.H.E.R.S. in the thick of it. Who or what is behind this organization and what is their true goals? Where are the heroes of the Second Bloody Valentine War?